New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance ( P

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Veröffentlicht in:Nature communications 2016-02, Vol.7 (1), p.10495-15, Article 10495
Hauptverfasser: Lu, Yingchang, Gustafsson, Stefan, Cousminer, Diana L., Evans, David M., Ferreira, Teresa, Hedman, Åsa K., Haring, Robin, Iles, Mark M., Kanoni, Stavroula, Li, Rui, Sanna, Marianna, Scott, William R., Teumer, Alexander, Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zhang, Weihua, Zhu, Zhihong, Bakker, Stephan J. L., Borodulin, Katja, Buchman, Aron S., Choi, Hyung Jin, Curran, Joanne E., Dhonukshe-Rutten, Rosalie A. M., Enneman, Anke W., Eury, Elodie, Fumeron, Frédéric, Garcia, Melissa E., Havulinna, Aki S., Hayward, Caroline, Hernandez, Dena, Ittermann, Till, Lahti, Jari, Leach, Irene Mateo, Lobbens, Stéphane, Lyytikäinen, Leo-Pekka, Nalls, Mike A., Oozageer, Laticia, Sarzynski, Mark A., Narančić, Nina Smolej, Spira, Dominik, Srikanth, Priya, Sung, Yun Ju, Tanaka, Toshiko, Wright, Alan F., Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Palmer, Cameron D., Ried, Janina S., Mcknight, Barbara, Menni, Cristina, Oostra, Ben A., Song, Kijoung, Forouhi, Nita G., Grallert, Harald, Hingorani, Aroon, Jousilahti, Pekka, Laakso, Markku, Linneberg, Allan, Luke, Amy, Palotie, Aarno, Tayo, Bamidele O., Bennett, David A., Blüher, Matthias, Bouchard, Claude, Demuth, Ilja, Ferrucci, Luigi, Franco, Oscar H., Harris, Tamara B., Heliövaara, Markku, Jordan, Joanne M., Knekt, Paul B., Koskinen, Seppo, Kovacs, Peter, Liu, Yongmei, Orwoll, Eric S., Osmond, Clive, Rudan, Igor, Stumvoll, Michael, Tönjes, Anke, Towne, Bradford, Tranah, Gregory J., Uitterlinden, André G., Vohl, Marie-Claude, Walker, Mark, Wild, Sarah, Bishop, D. Timothy, Borecki, Ingrid B., Chambers, John C., Cupples, L. Adrienne, Han, Jiali, Morris, Andrew P., Bishop, Julia A. N., Ohlsson, Claes, Ong, Ken K., Spector, Tim D., Willer, Cristen J., Yang, Jian, Hirschhorn, Joel N., Zillikens, M. Carola
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Sprache:eng
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Zusammenfassung:To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance ( P
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms10495