Accelerated epigenetic aging in women with emotionally unstable personality disorder and a history of suicide attempts

Emotional unstable personality disorder (EUPD; previously borderline personality disorder, BPD) is associated with excess natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. Previous studies demonstrated that GrimAge – a state-of-the-ar...

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Veröffentlicht in:Translational psychiatry 2023-02, Vol.13 (1), p.66-9, Article 66
Hauptverfasser: Boström, Adrian Desai E., Andersson, Peter, Jamshidi, Esmail, Wilczek, Alexander, Nilsonne, Åsa, Rask-Andersen, Mathias, Åsberg, Marie, Jokinen, Jussi
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Sprache:eng
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Zusammenfassung:Emotional unstable personality disorder (EUPD; previously borderline personality disorder, BPD) is associated with excess natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. Previous studies demonstrated that GrimAge – a state-of-the-art epigenetic age (EA) estimator – strongly predicts mortality risk and physiological dysregulation. Herein, we utilize the GrimAge algorithm to investigate whether women with EUPD and a history of recent suicide attempts exhibit EA acceleration (EAA) in comparison to healthy controls. Genome-wide methylation patterns were measured using the Illumina Infinum Methylation Epic BeadChip in whole blood from 97 EUPD patients and 32 healthy controls. The control group was significantly older ( p  
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-023-02369-7