Telomere length in healthy newborns is not affected by adverse intrauterine environments
Different intrauterine exposures are associated with different metabolic profiles leading to growth and development characteristics in children and also relate to health and disease patterns in adult life. The objective of this work was to evaluate the impact of four different intrauterine environme...
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Veröffentlicht in: | Genetics and molecular biology 2021-01, Vol.44 (4), p.e20200411-e20200411 |
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Sprache: | eng |
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Zusammenfassung: | Different intrauterine exposures are associated with different metabolic profiles
leading to growth and development characteristics in children and also relate to
health and disease patterns in adult life. The objective of this work was to
evaluate the impact of four different intrauterine environments on the telomere
length of newborns. This is a longitudinal observational study using a
convenience sample of 222 mothers and their term newborns (>37 weeks of
gestational age) from hospitals in Porto Alegre, Rio Grande do Sul (Brazil),
from September 2011 to January 2016. Sample was divided into four groups:
pregnant women with Gestational Diabetes Mellitus (DM) (n=38), smoking pregnant
women (TOBACCO) (n=52), mothers with small-for-gestational age (SGA) children
due to idiopathic intrauterine growth restriction (n=33), and a control group
(n=99). Maternal and newborn genomic DNA were obtained from epithelial mucosal
cells. Telomere length was assessed by qPCR, with the calculation of the
telomere and single copy gene (T/S ratio). In this sample, there was no
significant difference in telomere length between groups (p>0.05). There was
also no association between childbirth weight and telomere length in children
(p>0.05). For term newborns different intrauterine environments seems not to
influence telomere length at birth. |
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ISSN: | 1415-4757 1678-4685 1678-4685 |
DOI: | 10.1590/1678-4685-gmb-2020-0411 |