The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice

In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes. [Display omitted] •Optimization of optimal extraction conditions by response surface methodology.•Total flavonoids of Sedum aizoon L. have good antioxidant activity in vitro.•Total flavonoids of Sedum aizoon L. have hypoglycemic effect.•Total flavonoids of Sedum aizoon L. can improve the oxidative stress in T1DM mice.