Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis

Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal...

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Veröffentlicht in:Scientific reports 2020-07, Vol.10 (1), p.12102-12102, Article 12102
Hauptverfasser: Bigna, Jean Joel, Tochie, Joel Noutakdie, Tounouga, Dahlia Noelle, Bekolo, Anne Olive, Ymele, Nadia S., Youda, Emilie Lettitia, Sime, Paule Sandra, Nansseu, Jobert Richie
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Sprache:eng
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Zusammenfassung:Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal Online to identify studies that reported enough data to compute the immunoglobulins (Ig) M or G seroprevalence estimates of Toxoplasma gondii in pregnant women up to December 31st, 2018, without any language restriction. The global and regional estimates were done using a random-effects meta-analysis. We included 250 studies with 723,655 pregnant women. The global IgM seroprevalence was 1.9% (95%CI: 1.7–2.3). At the regional level, Eastern Mediterranean had the highest IgM seroprevalence (4.1%, 95%CI: 2.8–5.5) and The Americas, the lowest (1.1%, 0.8–1.4), with a statistically significant difference between WHO regions ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-69078-9