Comparing Framingham risk score and cognitive performance in a Mexican American cohort

•The utility of Framingham 10-year cardiovascular risk score (FCDVRS) specific to the Mexican American population.•The high predictive ability of FCDVRS in certain measures of cognitive function.•Groups with higher FCVDRS score had greater differences in cognitive performance.•An intriguing gender specific response: the association of FCDVRS and cognitive performance was stronger in females than in males. Mexican-Americans have a higher prevalence of modifiable cardiovascular risk factors as compared to Non-Hispanic whites. This study aims to elucidate the utility of the Framingham Cardiovascular Disease Risk Score (FCVDRS) as a predictor of cognitive performance on a cohort of Mexican Americans elders. 429 Mexican-Americans (338 female and 91 male) from a longitudinal study conducted at The University of North Texas Health Science Center were studied. Demographic and clinical data relevant to Framingham Cardiovascular Disease 10-year Risk Score (FCVDRS) were assessed. FCVDRS was calculated based on Body Mass Index (BMI) and categorized as Low if 20. Cognitive performance on Trails B, Wechsler Logical Memory I and II, Mini Mental State Examination (MMSE), and Animal Naming (AN) tests. Demographic data was analyzed using t-tests and chi-square tests as appropriate. Pearson correlation tests and ANOVAs were used to compare FCVDRS, as a continuous variable and as a categorical variable, against cognitive performance. Both Pearson correlation tests and linear regression analysis, showed significant correlations between FCVDRS and performance on 4 of the 8 measures of cognitive performance. ANOVAs with Post-Hoc analysis also showed that the difference in cognitive performance was more pronounced between groups with greater differences in FCVDRS. In all analyses, the strength of the relationship was stronger in females. The results show that FCDVRS has high predictive utility in measures of cognitive function. Gender specific analysis between FCVDRS and cognitive performance indicate a stronger association in females.