Comparing the Hemodynamic Changes during and after Coronary Artery Bypass Graft Surgery under General Anesthesia with Propofol and Isoflurane

Background: Hemodynamic changes during and after coronary artery bypass graft surgery and the effects of these changes on postoperative complications are important. As there was not any study to compare the effects of propofol and isoflurane on hemodynamic changes during and after coronary artery bypass grafting, we decided to do this. Methods: This clinical trial study was done on 80 patients undergoing coronary artery bypass surgery at the ages of 40 to 70 years in 2014 in Chamran Hospital, Isfahan, Iran. The subjects received isoflurane or propofol in two groups. Hemodynamic changes during coronary artery bypass graft surgery and then every 30 minutes until the end of the surgery and in intensive care unit every two hours to eight hours were compared. Findings: Based on the repeated measure ANOVA test, the differences between the two groups in systolic blood pressure (P = 0.475), diastolic blood pressure (P = 0.885), heart rate (P = 0.130), pulse pressure (P = 0.572) and arterial oxygen saturation (P = 0.425) in 10 times of measuring (before the pumping starts, at pumping, 30, 60, 90 and 120 minutes later, immediately after the pumping and 2, 6 and 8 hours after admission to the intensive care unit) were not significant. Conclusion: In our study, isoflurane and propofol did not cause significant differences in the hemodynamic variables before, during and after coronary artery bypass graft surgery.