Abnormal physiological findings after FFR-based revascularisation deferral are associated with worse prognosis in women

The prognostic value of abnormal resting Pd/Pa and coronary flow reserve (CFR) after fractional flow reserve (FFR)-guided revascularisation deferral according to sex remains unknown. From the ILIAS Registry composed of 20 hospitals globally from 7 countries, patients with deferred lesions following...

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Veröffentlicht in:Scientific reports 2023-01, Vol.13 (1), p.1027-1027, Article 1027
Hauptverfasser: Hoshino, Masahiro, van de Hoef, Tim P., Lee, Joo Myung, Hamaya, Rikuta, Kanaji, Yoshihisa, Boerhout, Coen K. M., de Waard, Guus A., Jung, Ji-Hyun, Lee, Seung Hun, Mejia-Renteria, Hernan, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A., Marques, Koen, Doh, Joon-Hyung, Christiansen, Evald H., Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Murai, Tadashi, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Sasano, Tetsuo, Appelman, Yolande, Beijk, Marcel, Knaapen, Paul, van Royen, Niels, Escaned, Javier, Koo, Bon Kwon, Piek, Jan J., Kakuta, Tsunekazu
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Sprache:eng
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Zusammenfassung:The prognostic value of abnormal resting Pd/Pa and coronary flow reserve (CFR) after fractional flow reserve (FFR)-guided revascularisation deferral according to sex remains unknown. From the ILIAS Registry composed of 20 hospitals globally from 7 countries, patients with deferred lesions following FFR assessment (FFR > 0.8) were included. (NCT 04485234) The primary clinical endpoint was target vessel failure (TVF) at 2-years follow-up. We included 1392 patients with 1759 vessels (n = 564 women, 31.9%). Although resting Pd/Pa was similar between the sexes ( p  = 0.116), women had lower CFR than men (2.5 [2.0–3.2] vs. 2.7 [2.1–3.5]; p  = 0.004). During a 2-year follow-up period, TVF events occurred in 56 vessels (3.2%). The risk of 2-year TVF was significantly higher in women with low versus high resting Pd/Pa (HR: 9.79; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-28146-6