Abnormal physiological findings after FFR-based revascularisation deferral are associated with worse prognosis in women
The prognostic value of abnormal resting Pd/Pa and coronary flow reserve (CFR) after fractional flow reserve (FFR)-guided revascularisation deferral according to sex remains unknown. From the ILIAS Registry composed of 20 hospitals globally from 7 countries, patients with deferred lesions following...
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Veröffentlicht in: | Scientific reports 2023-01, Vol.13 (1), p.1027-1027, Article 1027 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The prognostic value of abnormal resting Pd/Pa and coronary flow reserve (CFR) after fractional flow reserve (FFR)-guided revascularisation deferral according to sex remains unknown. From the ILIAS Registry composed of 20 hospitals globally from 7 countries, patients with deferred lesions following FFR assessment (FFR > 0.8) were included. (NCT 04485234) The primary clinical endpoint was target vessel failure (TVF) at 2-years follow-up. We included 1392 patients with 1759 vessels (n = 564 women, 31.9%). Although resting Pd/Pa was similar between the sexes (
p
= 0.116), women had lower CFR than men (2.5 [2.0–3.2] vs. 2.7 [2.1–3.5];
p
= 0.004). During a 2-year follow-up period, TVF events occurred in 56 vessels (3.2%). The risk of 2-year TVF was significantly higher in women with low versus high resting Pd/Pa (HR: 9.79;
p |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-023-28146-6 |