Prostate-specific membrane antigen positron emission tomography/computed tomography as a potential tool to assess and guide salivary gland irradiation

•PSMA PET/CT allows visualisation of salivary glands with good spatial and contrast resolution.•Evaluable glands include minor and less well-known gland locations.•PSMA PET/CT can visualise damage to salivary glands from external beam radiotherapy.•PSMA PET/CT has the potential to guide optimisation...

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Veröffentlicht in:Physics and imaging in radiation oncology 2019-01, Vol.9, p.65-68
Hauptverfasser: Valstar, Matthijs H., Owers, Emilia C., Al-Mamgani, Abrahim, Smeele, Ludwig E., van de Kamer, Jeroen B., Sonke, Jan-Jakob, Vogel, Wouter V.
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Sprache:eng
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Zusammenfassung:•PSMA PET/CT allows visualisation of salivary glands with good spatial and contrast resolution.•Evaluable glands include minor and less well-known gland locations.•PSMA PET/CT can visualise damage to salivary glands from external beam radiotherapy.•PSMA PET/CT has the potential to guide optimisation of radiotherapy to the head and neck.•The potential benefit of PSMA PET/CT is to avoid salivary gland toxicity and preserve quality of life. Evaluation of salivary gland damage after head and neck radiotherapy (RT) is difficult with current tools, such as subjective patient-reported outcome measures. We demonstrate the use of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) as an objective non-invasive tool to visualize damage to salivary glands resulting from RT. In three clinical cases, the PSMA-ligand distribution correlates to the RT dose distribution including intra-gland dose gradients and matches patient-reported toxicity, suggesting a dose-response relation. These findings support further exploration of PSMA PET/CT to guide and evaluate RT, with the ultimate aim to reduce salivary gland toxicity.
ISSN:2405-6316
2405-6316
DOI:10.1016/j.phro.2019.02.004