The Tumor Suppressive mir-148a Is Epigenetically Inactivated in Classical Hodgkin Lymphoma

The Tumor Suppressive mir-148a Is Epigenetically Inactivated in Classical Hodgkin Lymphoma

DNA methylation was shown previously to be a crucial mechanism responsible for transcriptional deregulation in the pathogenesis of classical Hodgkin lymphoma (cHL). To identify epigenetically inactivated miRNAs in cHL, we have analyzed the set of miRNAs downregulated in cHL cell lines using bisulfit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cells (Basel, Switzerland) Switzerland), 2020-10, Vol.9 (10), p.2292
Hauptverfasser: Paczkowska, Julia, Janiszewska, Joanna, Bein, Julia, Schneider, Markus, Bednarek, Kinga, Ustaszewski, Adam, Hartmann, Sylvia, Hansmann, Martin-Leo, Giefing, Maciej
Format: Artikel
Sprache:eng
Schlagworte:
Bisulfite
Cell Line, Tumor
Cell proliferation
Cell Proliferation - genetics
cHL
CpG islands
Deoxyribonucleic acid
DNA
DNA Methylation
Down-Regulation - genetics
Epigenesis, Genetic
epigenetic
Epigenetic inheritance
Epigenetics
Gene expression
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Genetic aspects
Health aspects
HEK293 Cells
Hodgkin Disease - genetics
Hodgkin Disease - pathology
Hodgkin's disease
Hodgkin's lymphoma
Humans
Interleukin 1
Interleukin 15
Lymphatic system
Lymphoma
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
mir-148a
miRNA
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Pathogenesis
Promoter Regions, Genetic
Transcription
Transcription, Genetic
Tumor suppressor genes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:DNA methylation was shown previously to be a crucial mechanism responsible for transcriptional deregulation in the pathogenesis of classical Hodgkin lymphoma (cHL). To identify epigenetically inactivated miRNAs in cHL, we have analyzed the set of miRNAs downregulated in cHL cell lines using bisulfite pyrosequencing. We focused on miRNAs with promoter regions located within or
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9102292