Letter to the editor regarding "Rotavirus infection beyond the gut"

Alejandro Orrico-Sánchez,1 Mónica López-Lacort,1 Cintia Muñoz-Quiles,1 Miguel Angel Martinez-Beneito,2 Javier Díez-Domingo11Vaccine Research, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Valencia, Spain; 2Health Inequalities, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Valencia, SpainGomez-Rial et al, in their review paper "Rotavirus infection beyond the gut",1concluded that there is some degree of protection of the RV vaccination againstseizure hospitalizations. A detailed analysis of the potential biases of the literaturecould lead to a less optimistic position for the vaccine. For example, the protectionfound in the USA and Australia could be partly due to the uncontrolled influenzavaccine (where the coverage in children under 5 years in EEUU reached 66-75%2).Other studies have small sample sizes, or used poorly adjusted analyses.Beyond their different degrees of appraisal of the papers depending on the directionof the results, there is a lack of discussion of the publication bias, as this bias disruptsthe literature promoting positive findings and hiding negative results.View the original paper byGomez-Rial and colleagues.