Assessment of Non-surgical Periodontal Therapy on IL-22 and S100A12 Concentration in Gingival Crevicular Fluid

Introduction: Periodontitis is a disease of the periodontal tissues that results in attachment loss and destruction of alveolar bone. Several risk factors such as bacteria, the host immune responses and genetics are considered. Aim: The present study was undertaken to evaluate the effect of phase I periodontal treatment on the concentrations of IL-22 and S100A12 in patients with chronic periodontitis. Correlation between PD and CAL with the concentrations of IL-22 and S100A12 was also evaluated. Materials and Methods: In this study, 22 patients (14 female and 8 male), with a mean age of 39.55±10.25 years, and moderate to severe periodontitis were included. GCF samples were obtained and then Phase I periodontal treatment was rendered. The subjects were recalled after four weeks for collecting samples. Wilcoxon’s signed-rank test was used to analyse concentration of S100 and IL-22 before and after the treatment with CAL and PD. Results: There was an inverse correlation between the mean PD and S100 before treatment (p