Association of Cyclic RNAs with the Risk of Type 2 Diabetes Mellitus in Han Chinese

Background The prevalence of diabetes is increasing year-on-year. However, current diagnostic methods have many deficiencies in early identification of type 2 diabetes mellitus (T2DM) . Epigenetic factors may be associated with the development and secretory function of pancreatic islet β cells, which reduces the sensitivity of the body to the effects of insulin, ultimately leading to the development of T2DM. Objective To identify differentially expressed hsa_circ_0005414, hsa_circ_0139634, hsa_circ_0032491 and hsa_circ_0002922 in the peripheral blood of Han Chinese patients with T2DM to assess the clinical significance, and to explore the relationship between candidate circRNAs and T2DM in Han Chinese. Methods From the Department of Endocrinology and Metabolism, the First Affiliated Hospital of Shihezi University School of Medicine between September 2020 and June 2021, 21 Han Chinese patients with T2DM were selected. 22 healthy examinees were also selected as controls. Glucose metabolism indices and expressio