CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway

Explores whether and how Cullin 4A (CUL4A) regulates proinflammatory signaling to promote gastric cancer (GC) cell invasion. Hypothesises that overexpression of CUL4A may promote GC cell invasion by activating the nuclear factor-kappa B (NF-κB) pathway. Demonstrates that downregulation of CUL4A expression leads to the inhibition of GC cell invasion induced by lipopolysaccharide (LPS) stimulation and that knockdown of CUL4A decreases the expression of NF-κB and its downstream target genes. Suggests that the results indicate that CUL4A/NF-κB signaling may be involved in the invasion of GC. Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons Attribution 3.0 New Zealand Licence.