The Life-Cycle of the HIV-1 Gag-RNA Complex

Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA...

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Veröffentlicht in:	Viruses 2016-09, Vol.8 (9), p.248
Hauptverfasser:	Mailler, Elodie, Bernacchi, Serena, Marquet, Roland, Paillart, Jean-Christophe, Vivet-Boudou, Valérie, Smyth, Redmond P
Format:	Artikel
Sprache:	eng
Schlagworte:	assembly Gag gag Gene Products, Human Immunodeficiency Virus - metabolism genomic RNA HIV-1 HIV-1 - physiology Humans packaging Protein Binding Review RNA, Viral - metabolism Virus Assembly
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA (gRNA) by the viral Pr55(Gag) precursor polyprotein, and the processes leading to its incorporation into viral particles.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v8090248