Pro-inflammatory cerebrospinal fluid profile of neonates with intraventricular hemorrhage: clinical relevance and contrast with CNS infection

Pro-inflammatory cerebrospinal fluid profile of neonates with intraventricular hemorrhage: clinical relevance and contrast with CNS infection

Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningitis) promote pro-inflammatory CSF conditions reflected in CSF parameters. Biochemical and cyt...

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Veröffentlicht in:Fluids and barriers of the CNS 2024-02, Vol.21 (1), p.17-10, Article 17
Hauptverfasser: Garcia-Bonilla, Maria, Yahanda, Alexander T, Isaacs, Albert M, Baksh, Brandon, Akbari, S Hassan A, Botteron, Haley, Morales, Diego M, Han, Rowland H, McAllister Ii, James P, Mathur, Amit M, Strahle, Jennifer M, Smyser, Christopher D, Limbrick, Jr, David D
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Aseptic meningitis
Bacterial Meningitis
Blood cell count
Blood platelets
Cell culture
Cerebrospinal fluid
CNS infection
Dextrose
Diagnostic tests
Erythrocytes
Gestational age
Glucose
Glycosylated hemoglobin
Hematocrit
Hemoglobin
Hemorrhage
Hydrocephalus
Infants
Infants (Premature)
Infections
Inflammation
Intraventricular hemorrhage
Leukocytes (neutrophilic)
Lung diseases
Meningitis
Neonates
Neutrophils
Newborn babies
Patients
Peripheral blood
Post-hemorrhagic hydrocephalus
Premature birth
Prematurity
Proteins
Respiratory distress syndrome
Sepsis
Steroids
Ultrasonic imaging
Variance analysis
Ventriculitis
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Zusammenfassung:Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningitis) promote pro-inflammatory CSF conditions reflected in CSF parameters. Biochemical and cytological profiles of lumbar CSF and peripheral blood samples were analyzed for 81 control, 29 IVH grade 1/2 (IVH ), 13 IVH grade 3/4 (IVH ), 15 PHH, 20 culture-confirmed bacterial meningitis (BM), and 27 viral meningitis (VM) infants at 36.5 ± 4 weeks estimated gestational age. PHH infants had higher (p 
ISSN:2045-8118
2045-8118
DOI:10.1186/s12987-024-00512-0