A study of urinary prostacylin products and some haematological parameters in pregnant women with sickle cell anaemia

A study of urinary prostacylin products and some haematological parameters in pregnant women with sickle cell anaemia

Objective: Normal gestation is associated with an increased plasma volume (PV) and vasodilation which plasma prostacyclin (PGI2) may account for. This study measured PGI2 levels in pregnant haemoglobin (Hb) SS patients as they have been reported to lack PV expansion. Methods: Urinary prostacyclin (U...

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Veröffentlicht in:Journal of clinical sciences 2013, Vol.10 (1), p.6-10
Hauptverfasser: Akanmu, AS, Afolabi, BB, Taiwo-Osinubi, PA, Abudu, OO
Format: Artikel
Sprache:eng
Schlagworte:
haematological
pregnancy
sickle cell anaemia
Urinary prostacyclin
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Zusammenfassung:Objective: Normal gestation is associated with an increased plasma volume (PV) and vasodilation which plasma prostacyclin (PGI2) may account for. This study measured PGI2 levels in pregnant haemoglobin (Hb) SS patients as they have been reported to lack PV expansion. Methods: Urinary prostacyclin (UP) concentration and full blood count parameters were determined in pregnant Hb AA and Hb SS women, with non-pregnant controls. Results: Thirty-three Hb AA (19 non-pregnant and 14 pregnant) and 25 Hb SS (18 non-pregnant and 7 pregnant) were studied. UP did not rise in pregnant Hb SS women compared to non-pregnant (Geometric mean (GM) 614 ± 2.4 vs 248 ± 3.8, p=0.063), despite a very significant rise in Hb AA pregnancy (GM 1406 ± 2.1 vs 260 ± 2.9 pg/ml, p
ISSN:2468-6859
2408-7408
DOI:10.4103/2468-6859.143849