Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location

•This is the first study on LODDS and ENE together. The current study showed that LODDS and ENE are liable prognostic parameters of CRC or CC.•ENE is an independent influencing factor on the prognosis of both CRC and CC, and the prognostic impact of ENE was observed in both CRC and CC.•The frequency of ENE increases from the proximal (right) to the distal (left) colon as well as the rectum. Extranodal extension (ENE) and log odds of positive lymph nodes (LODDS) are associated with the aggressiveness of both colon and rectal cancers. The current study evaluated the clinicopathological significance and the prognostic impact of ENE and LODDS in the colon and rectal patients independently. The clinical and histological records of 389 colorectal cancer (CRC) patients who underwent curative surgery were reviewed. For the ENE system, 244 patients were in the ENE1 group and 145 in the ENE2 system. Compared with the ENE1 system, the patients included in the ENE2 system were prone to nerve invasion (P