Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives

A series of 1,3,4-oxadizole derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were characterized and evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli and Baci...

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Veröffentlicht in:Arabian journal of chemistry 2016-11, Vol.9 (S2), p.S1029-S1035
Hauptverfasser: Khalilullah, Habibullah, Khan, Shamshir, Nomani, Md. Shivli, Ahmed, Bahar
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Sprache:eng
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Zusammenfassung:A series of 1,3,4-oxadizole derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were characterized and evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis and antifungal activity against Aspergillus niger, Aspergillus flavus and Candida albicans by twofold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs norfloxacin, chloramphenicol and fluconazole, against tested strains.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2011.11.009