Leukodystrophy without Ovarian Failure Caused by Compound Heterozygous Alanyl-tRNA Synthetase 2 Mutations

To the Editor：Mutations in the mitochondrial alanyl-tRNA synthetase 2 gene （AARS2） have been recently found to lead to chronic progressive leukodystrophy or infantile cardiomyopathy.Up to date,there have been 15 patients reported with chronic progressive leukodystrophy.Notably,all the female patients （9/15） present with ovarian failure,described as ＆quot;ovarioleukodystrophy.＆quot;[1-4] Herein,we report a female patient with progressive adult-onset leukodystrophy without ovarian failure due to compound heterozygous mutations in AARS2.