A Glucagonoma Presenting as Cerebral Vein Thrombosis and Diabetes

Glucagonomas are rare pancreatic neuroendocrine tumors (pNETs), malignant in 80% of cases, thus highlighting the importance of early diagnosis and treatment. Primary manifestations are diabetes, dermatosis, depression, weight loss, and deep vein thrombosis. Unlike other pNETs, glucagonomas are assoc...

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Veröffentlicht in:Case reports in endocrinology 2022-04, Vol.2022, p.7659341-3
Hauptverfasser: Delli Colli, Marina, Alamri, Bader N., Palma, Laura, Rivera, Juan
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Sprache:eng
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Zusammenfassung:Glucagonomas are rare pancreatic neuroendocrine tumors (pNETs), malignant in 80% of cases, thus highlighting the importance of early diagnosis and treatment. Primary manifestations are diabetes, dermatosis, depression, weight loss, and deep vein thrombosis. Unlike other pNETs, glucagonomas are associated with a higher incidence of thromboembolic events, often resulting in death. We present the case of a glucagonoma patient whose primary manifestation was cerebral sinus venous thrombosis (CS-VT). Early diagnosis enabled curative resection. The purpose of this paper is to review the underlying mechanisms associated with increased coagulopathy in glucagonomas.
ISSN:2090-6501
2090-651X
DOI:10.1155/2022/7659341