Research progress in Berger's space: An interesting retrolenticular space

In recent years, Berger's space (BS), the potential space between the posterior lens capsule and the anterior hyaloid membrane, has received little attention from the ophthalmic clinical community. This is primarily due to the limited documentation, with only a few isolated case reports detailing foreign bodies in this area. Recent advances in medical imaging technology have enabled the visualization of the BS under various circumstances. This progress has deepened clinicians' understanding of this elusive structure, allowing ophthalmic surgeons to utilize this space better and enhancing the safety and efficacy of relevant surgical procedures. This study explored the discovery, anatomical features, and clinical significance of the BS through anatomical and clinical studies. This review emphasizes the observation of the BS via different imaging methods, the changes in the BS following the entry of abnormal substances, and its application in specific intraocular surgical procedures.