Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum

Inflatin G ( ), a new aphidicolin analogue, together with seven known compounds inflatin A ( ), inflatin B ( ), aphidicolin ( ), aphidicolin-17-monoacetate ( ), gulypyrone A ( ), pyridoxatin rotamers A ( ) and B ( ), were isolated from the ascomycete fungus . Their structures were determined through...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2017-07, Vol.22 (7), p.1168
Hauptverfasser:	Lin, Jie, Niu, Shubin, Ding, Zhengfeng, Wang, Renlei, Dai, Qun, Wei, Wei, Luo, Rongrong, Liu, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Aphidicolin Aphidicolin - analogs & derivatives Aphidicolin - chemistry Aphidicolin - isolation & purification Aphidicolin - pharmacology biological activities Cancer Cell Line, Tumor Cell Proliferation - drug effects Circular dichroism Cytotoxicity Dichroism Drug Screening Assays, Antitumor Fungi Humans Hypocreales - chemistry Laboratories Natural products structure elucidation Tolypocladium inflatum Tumor cell lines
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Zusammenfassung:	Inflatin G ( ), a new aphidicolin analogue, together with seven known compounds inflatin A ( ), inflatin B ( ), aphidicolin ( ), aphidicolin-17-monoacetate ( ), gulypyrone A ( ), pyridoxatin rotamers A ( ) and B ( ), were isolated from the ascomycete fungus . Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh₂(OCOCF₃)₄] complexes. Compounds , , , , and showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules22071168