Immunostimulatory Activity of Tilapia-head Chondroitin Sulfate in RAW 264.7 Cells and Mice

Immunostimulatory Activity of Tilapia-head Chondroitin Sulfate in RAW 264.7 Cells and Mice

In this study, RAW 264.7 cells and immunosuppressive models were used to investigate the immunostimulatory activity of tilapia-head chondroitin sulfate (CS) through in vitro and in vivo experiments. The results showed that tilapia-head chondroitin sulfate (CS) could induce the produce of NO, IL-1β,...

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Veröffentlicht in:Shipin gongye ke-ji 2024-12, Vol.45 (23), p.381-387
Hauptverfasser: Houpei HUANG, Yuan YUAN, Zhuo WANG, Jing CHEN, Bingbing SONG, Saiyi ZHONG
Format: Artikel
Sprache:chi
Schlagworte:
chondroitin sulfate
immunostimulatory activity
immunosuppression
intestinal barrier
raw 264.7
tilapia
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Zusammenfassung:In this study, RAW 264.7 cells and immunosuppressive models were used to investigate the immunostimulatory activity of tilapia-head chondroitin sulfate (CS) through in vitro and in vivo experiments. The results showed that tilapia-head chondroitin sulfate (CS) could induce the produce of NO, IL-1β, IL-6, IL-10 and TNF-α in RAW 264.7 cells. Cyclophosphamide (CTX) induced thymic atrophy in mice (thymic index 0.11%±0.01%), while thymic index was significantly up-regulated by low-dose CS (thymic index (0.17%±0.03%) and high-dose CS (thymic index (0.18%±0.02%) interventions (P
ISSN:1002-0306
DOI:10.13386/j.issn1002-0306.2023120214