Global Stability of Within-Host Virus Dynamics Models with Multitarget Cells

In this paper, we study the stability analysis of two within-host virus dynamics models with antibody immune response. We assume that the virus infects n classes of target cells. The second model considers two types of infected cells: (i) latently infected cells; and (ii) actively infected cells that produce the virus particles. For each model, we derive a biological threshold numberR0. Using the method of Lyapunov function, we establish the global stability of the steady states of the models. The theoretical results are confirmed by numerical simulations.