Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207

Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207

A novel indole, microindolinone A ( ), was isolated from a deep-sea-derived actinomycete sp. MCCC 1A11207, together with 18 known compounds ( - ). By detailed analysis of the ¹H, C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circular dichroism (CD) data,...

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Veröffentlicht in:Marine drugs 2017-07, Vol.15 (7), p.230
Hauptverfasser: Niu, Siwen, Zhou, Ting-Ting, Xie, Chun-Lan, Zhang, Gai-Yun, Yang, Xian-Wen
Format: Artikel
Sprache:eng
Schlagworte:
Absolute configuration
Actinobacteria - chemistry
Actinomycetales - chemistry
actinomycete
Circular dichroism
Circular Dichroism - methods
Communication
Deep sea
Deep sea environments
Deep water
Dichroism
Drugs
Gram-positive bacteria
indole
Indoles
Indoles - chemistry
Ionization
Laboratories
Magnetic Resonance Spectroscopy - methods
Microbacterium sp
Molecular Structure
Oceanography
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Beschreibung
Zusammenfassung:A novel indole, microindolinone A ( ), was isolated from a deep-sea-derived actinomycete sp. MCCC 1A11207, together with 18 known compounds ( - ). By detailed analysis of the ¹H, C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circular dichroism (CD) data, the absolute configuration of was elucidated as 5 -hydroxy-4,5,6,7-tetrahydroindole-4-one. It is noteworthy that is the second example of a saturated indole isolated from nature.
ISSN:1660-3397
1660-3397
DOI:10.3390/md15070230