DISSOLUTION MEDIA USED IN DEVELOPMENT AND QUALITY CONTROL OF DRUGS

The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown. Based on the analysis of dissolution media authors concluded that it’s necessary to select appropriate dissolution conditions for particular drug. These dissolution conditions should be able to ensure the stability of the active pharmaceutical ingredients throughout the whole stage of the study. Moreover, when developing a dissolution medium, the researcher needs to take into account the chemical structure of the active pharmaceutical ingredients in the drug, the composition of the auxiliary substances and the site of the gastrointestinal tract, where the API dissolves.