Nanopharmaceuticals (Au-NPs) after use: Experiences with a complex higher tier test design simulating environmental fate and effect

The current environmental hazard assessment is based on the testing of the pristine substance. However, it cannot be excluded that (nano)pharmaceuticals are excreted into sewage during the use phase followed by entry into wastewater treatment plants (WWTPs). Sorption to sewage sludge or release via...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Ecotoxicology and environmental safety 2021-12, Vol.227, p.112949, Article 112949
Hauptverfasser: Hund-Rinke, Kerstin, Diaz, Cecilia, Jurack, Anne, Klein, Judith, Knopf, Burkhard, Schlich, Karsten, Fernández-Cruz, María Luisa, Hernández-Moreno, David, Manier, Nicolas, Pandard, Pascal, Gomes, Susana I.L., Guimarães, Bruno, Scott-Fordsmand, Janeck J., Amorim, Mónica J.B.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The current environmental hazard assessment is based on the testing of the pristine substance. However, it cannot be excluded that (nano)pharmaceuticals are excreted into sewage during the use phase followed by entry into wastewater treatment plants (WWTPs). Sorption to sewage sludge or release via effluent can result in modified ecotoxicological effects which possibly can only be detected with a modified test approach. The objective of our study was to investigate a realistic exposure scenario for metallic nanoparticles (NPs) in pharmaceutical products, excreted into effluent, and released into the environment after treatment in WWTPs. The test approach was illustrated by using gold (Au) NPs. Effluent from model WWTPs were investigated in aquatic tests (Daphnia magna, fish cell lines). Sewage sludge was used as a sole food source (Eisenia fetida) or mixed with soil and used as test medium (soil microorganisms, Folsomia candida, Enchytraeus crypticus). To cover the aspect of regulation, the test systems described in OECD-test guidelines (OECD TG 201, 211, 220, 232, 249, 317) were applied. Modifications and additional test approaches were included to meet the needs arising out of the testing of nanomaterials and of the exposure scenarios. The results were assessed regarding the suitability of the test design and the toxicity of Au-NPs. Except for activated sludge as a sole food source for E.fetida, the selected test approach is suitable for the testing of nanomaterials. Additional information can be gained when compared to the common testing of the pristine nanomaterials in the standardized test systems. Effects of Au-NPs were observed in concentrations exceeding the modeled environmental. [Display omitted] •Proposal of a higher test design for nanopharmaceuticals exemplified for nano gold.•Simulation of wastewater treatment plants followed by soil and aquatic tests is feasible.•Low risk of medical applied Au expected for soil invertebrates, daphnids.•Effects on microbial community structure unlike microbial function and fish cells are not excluded.•Aging of Au-NPs during the process in the WWTP induces toxicity in the fish cells.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2021.112949