New 18(4→3) -Abeo -Abietanoids from Tripterygium wilfordii

New 18(4→3) -Abeo -Abietanoids from Tripterygium wilfordii

Three 18(4→3) -abietanoids, a new natural product and two new compounds, named tripordolides A⁻C ( ⁻ ), were isolated from the leaves of Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallog...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2018-09, Vol.23 (10), p.2467
Hauptverfasser: Ni, Lin, Zang, Ying-da, Yang, Jing-Zhi, Li, Chuang-Jun, Ma, Jie, Zhang, Dong-Ming
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cells, Cultured
Diterpenes, Abietane - pharmacology
Lipopolysaccharides - pharmacology
Macrophages - cytology
Macrophages - drug effects
Macrophages - metabolism
Mice
Nitric Oxide - analysis
Nitric Oxide - metabolism
Plant Extracts - pharmacology
Plant Leaves - chemistry
tripordolide
Tripterygium - chemistry
Tripterygium wilfordii
X-ray
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Zusammenfassung:Three 18(4→3) -abietanoids, a new natural product and two new compounds, named tripordolides A⁻C ( ⁻ ), were isolated from the leaves of Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu α radiation. Compounds and showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23102467