Weight outcome after 2 years of a diet that excludes six processed foods: exploratory study of the "1,2,3 diet" in a moderately obese population

The Paleolithic diet, a diet devoid of food-processing procedure, seems to produce a greater decrease in weight compared to healthy reference diets but its limited food choices make it difficult to implement in our modern times where refined food is dominant. To evaluate the effects of a 2-year diet that excludes only six refined foodstuffs implicated in obesity. Professional contact was kept minimal to approximate the approach used by most dieters. Single-arm, open-label, exploratory study. One academic medical center, outpatient setting. One hundred and five subjects with a mean age of 50 (SD, 14 years) and mean body mass index of 30.5 kg/m (SD, 4 kg/m ). Thirty-nine percent had type 2 diabetes. An ad libitum diet that excludes six refined foodstuffs (margarine, vegetable oils, butter, cream, processed meat, and sugary drinks) called the "1,2,3 diet". Weight at 2 years was the primary outcome. Secondary outcomes included number of patients who lost more than 5% of initial body weight, glycated hemoglobin (HbA ) level, and changes in dietary behavior. Average weight loss was 4.8 kg (