Experimental model of traumatic ulcer in the cheek mucosa of rats Modelo experimental de úlcera traumática em mucosa jugal de ratos

Experimental model of traumatic ulcer in the cheek mucosa of rats Modelo experimental de úlcera traumática em mucosa jugal de ratos

PURPOSE: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The anima...

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Veröffentlicht in:Acta cirúrgica brasileira 2011-06, Vol.26 (3), p.227-234
Hauptverfasser: Galyléia Meneses Cavalcante, Renata Janaína Sousa de Paula, Leonardo Peres de Souza, Fabrício Bitu Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
Format: Artikel
Sprache:eng
Schlagworte:
Cicatrização de Feridas
Mouth Mucosa
Mucosa Bucal
Ratos
Rats
Ulcer
Wound Heling
Úlcera
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Zusammenfassung:PURPOSE: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p
ISSN:0102-8650
1678-2674
DOI:10.1590/S0102-86502011000300012