Immune-related health-relevant changes in natural populations of Norway rat (Rattus norvegicus Berkenhout, 1769): White blood cell counts, leukocyte activity, and peripheral organ infiltration

Basic immune-related health-relevant changes (total and differential white blood cell counts and activity, leukocyte tissue infiltration, and related pathohistology) were assessed in wild Norway rats from urban habitats. Comparative measurements were conducted in individuals of several laboratory strains of Norway rat in order to gain insight into environmental effects on the health of wild rats. Changes in leukocyte counts and activity along with tissue infiltration were noted only in wild rats, indicating systemic as well as tissue inflammation in these animals. Coincidence of these changes with chronic inflammatory pulmonary and kidney disease was observed in the majority of affected rats. U radu su ispitane osnovne imunoloske zdravstveno znacajne promene kod jedinki sivog pacova iz urbanih stanista (ukupan broj i diferencijalni sastav, kao i aktivnost leukocita periferne krvi, tkivna infiltracija leukocita i patohistoloske promene). Uporedo su radjena ispitivanja na nekoliko laboratorijskih sojeva pacova da bi se stekao uvid u efekte spoljasnje sredine na zdravlje jedinki iz prirodnih populacija. Promene u broju i aktivnosti leukocita, kao i infiltracija u organe su primecene samo kod jedinki iz prirodnih populacija i ukazuju na sistemsku i tkivnu inflamaciju kod tih jedinki. Kod vecine obolelih jedinki je pokazana povezanost ovih promena i hronicnih inflamatornih oboljenja pluca i bubrega.