The role of aging in cancer

Many cancers show an increase in incidence with age, and age is the biggest single risk factor for many cancers. However, the molecular basis of this relationship is poorly understood. Through a collection of review articles, our thematic issue discusses the link between aging and cancer in aspects...

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Veröffentlicht in:	Molecular oncology 2022-09, Vol.16 (18), p.3213-3219
Hauptverfasser:	Havas, Aaron, Yin, Shanshan, Adams, P. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - genetics Aging - metabolism Autophagy Colorectal cancer Colorectal carcinoma Diabetes DNA biosynthesis Epigenesis, Genetic Epigenetics Esophagus Evolution & development Fatty liver Growth hormones Humans Inflammation Insulin Life span Liver cancer Liver diseases Longevity Metabolic syndrome Metformin Mitochondria Mitochondria - genetics Mitochondria - metabolism Mutation Neoplasms - genetics Neoplasms - metabolism Nutrient deficiency Obesity Phenotypes Proteins Rapamycin Risk factors Senescence Stem cells Telomere - genetics
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Beschreibung
Zusammenfassung:	Many cancers show an increase in incidence with age, and age is the biggest single risk factor for many cancers. However, the molecular basis of this relationship is poorly understood. Through a collection of review articles, our thematic issue discusses the link between aging and cancer in aspects including somatic mutations, proteostasis, mitochondria, metabolism, senescence, epigenetic regulation, immune regulation, DNA damage, and telomere function.
ISSN:	1574-7891 1878-0261
DOI:	10.1002/1878-0261.13302