Relationships between biological aging and male reproductive monitors

Dear Editor, Advanced paternal age affects testicular function, reproductive hormones, and sperm parameters, but it is unclear whether chronological age or biological age exercises a greater sway on reproductive function. [...]the authors carried out this prospective, multicenter, observational study, in which sperm concentration; motility and morphology; ejaculated volume; testicular volume; and the blood concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone (T) were related to chronological and biological age. The exclusion criteria were the presence of any ejaculation disorder (42 patients), clinical varicocele (38 patients), previous genital surgery/trauma (15 patients), ongoing medical treatment (any type of antibiotic use, antitumoral treatments, nonsteroidal anti-inflammatory drugs, gonadotropins, and steroids; 12 patients), and any previous treatment for couple infertility (28 patients). [...]comorbidities are linked to aging and to an increase in biological age.