N -Cyclopropyl- N -[2-(2,4-difluorophenyl)-2-hydroxy-1-(1 H -1,2,4-triazol-1-yl)propyl]-2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetamide dichloromethane 0.62-solvate

In the title compound, C21H22F2N6O4·0.62CH2Cl2, the difluoro-substituted benzene ring forms dihedral angles of 54.6 (3)° with the mean plane of the thymine ring and 50.9 (2)° with the triazole ring. The dihedral angle between the thymine and triazole ri...

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Veröffentlicht in:Acta crystallographica. Section E, Structure reports online Structure reports online, 2011-09, Vol.67 (9), p.o2464-o2464
Hauptverfasser: Wang, Nan, Guo, Huan-Mei, Hou, Gui-Ge, Hu, Xin-Yue, Meng, Qing-Guo
Format: Artikel
Sprache:eng
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Zusammenfassung:In the title compound, C21H22F2N6O4·0.62CH2Cl2, the difluoro-substituted benzene ring forms dihedral angles of 54.6 (3)° with the mean plane of the thymine ring and 50.9 (2)° with the triazole ring. The dihedral angle between the thymine and triazole rings is 7.4 (3)°. In the crystal, intermolecular N—H...N and O—H...O hydrogen bonds link the main molecules into chains along [10overline{1}]. The CH2Cl2 solvent molecule was refined as partial occupancy over two sets of sites with refined occupancies of 0.308 (9) and 0.310 (8).
ISSN:1600-5368
1600-5368
DOI:10.1107/S1600536811034295