Association of proinflammatory genes expression with serum interleukin 1β and free fatty acids in metabolically healthy and unhealthy abdominally obese individuals: a case-control study

Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the metabolic state or the presence of obesity. Hence, the present study aimed to compare Toll-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BMC immunology 2019-07, Vol.20 (1), p.23-23, Article 23
Hauptverfasser:	Amiri, Parichehr, Baradaran, Behzad, Saghafi-Asl, Maryam, Naghizadeh, Mahsa, Shanehbandi, Dariush, Karamzad, Nahid, Vahed, Sepideh Zununi
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Abdominal obesity Adult Blood pressure Body mass index Case-Control Studies Cytokines Fatty acids Fatty Acids, Nonesterified - blood Female Gene Expression High density lipoprotein Humans IL-1β Inflammation Inflammation - genetics Interleukin-1beta - blood Male Metabolic Diseases - immunology Metabolic disorders MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid differentiation Factor88 NF-kappa B - genetics Nuclear factor kappa B, interleukin-1beta Obesity Obesity, Abdominal - immunology RNA, Messenger - genetics TLR2 protein Toll like receptor2 Toll-Like Receptor 2 - genetics Toll-like receptors Tumor necrosis factor-TNF Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the metabolic state or the presence of obesity. Hence, the present study aimed to compare Toll-Like Receptor 2 (TLR2), Myeloid Differentiation Factor 88 (MyD88), and NFĸB mRNA expression levels between metabolically healthy abdominally obese (MHAO) and metabolically unhealthy abdominally obese (MUAO) individuals. We compared mRNA expression levels of the genes as well as serum FFAs and IL-1β in MUAO (n = 36) and MHAO (n = 34) groups. Serum FBS, TG, and HDL-C in addition to systolic and diastolic blood pressure were significantly higher in MUAO than MHAO groups (p
ISSN:	1471-2172 1471-2172
DOI:	10.1186/s12865-019-0303-2