Generation of iPS cell line (ICGi040-A) from skin fibroblasts of a patient with ring small supernumerary marker chromosome 4

Generation of iPS cell line (ICGi040-A) from skin fibroblasts of a patient with ring small supernumerary marker chromosome 4

Human induced pluripotent stem cell (iPSC) line, ICGi040-A, was obtained from skin fibroblasts derived from a male patient with mosaic ring small supernumerary marker chromosome 4 (sSMS(4)) and infertility. ICGi040-A cells have karyotype 47,XY,+r(4) in 97% of cells and express a set of pluripotent m...

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Veröffentlicht in:Stem cell research 2022-05, Vol.61, p.102740-102740, Article 102740
Hauptverfasser: Gridina, M.M., Nurislamov, A.R., Minina, J.M., Lopatkina, M.E., Drozdov, G.V., Vasilyev, S.A., Minaycheva, L.I., Belyaeva, E.O., Nikitina, T.V., Kashevarova, A.A., Lebedev, I.N., Karamysheva, T.V., Rubtsov, N.B., Serov, O.L.
Format: Artikel
Sprache:eng
Schlagworte:
Cell Line
Chromosomes, Human, Pair 4
Fibroblasts - metabolism
Humans
Induced Pluripotent Stem Cells - metabolism
Karyotype
Male
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Zusammenfassung:Human induced pluripotent stem cell (iPSC) line, ICGi040-A, was obtained from skin fibroblasts derived from a male patient with mosaic ring small supernumerary marker chromosome 4 (sSMS(4)) and infertility. ICGi040-A cells have karyotype 47,XY,+r(4) in 97% of cells and express a set of pluripotent markers, as well as are able to differentiate in vitro into derivatives of all three embryonic germ layers.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2022.102740