Serum amyloid A4 is a procoagulant apolipoprotein that it is elevated in venous thrombosis patients

Serum amyloid A4 is a procoagulant apolipoprotein that it is elevated in venous thrombosis patients

Serum amyloid A4 (SAA4) is an apolipoprotein that is in the SAA family and it is constitutively translated. Previously, acute‐phase SAA1 and SAA2 levels were associated with venous thromboembolism (VTE). We investigated the association of plasma SAA4 with VTE and the role of SAA4 in coagulation. The...

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Veröffentlicht in:Research and practice in thrombosis and haemostasis 2020-02, Vol.4 (2), p.217-223
Hauptverfasser: Fernández, José A., Deguchi, Hiroshi, Elias, Darlene J., Griffin, John H.
Format: Artikel
Sprache:eng
Schlagworte:
Age
Blood & organ donations
Brief Report
Embolisms
factor Xa
Inflammation
Low density lipoprotein
Original : Thrombosis
Proteins
prothrombinase
serum amyloid A
serum amyloid A4
Statistical analysis
Studies
Thromboembolism
Thrombosis
venous thrombosis
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Beschreibung
Zusammenfassung:Serum amyloid A4 (SAA4) is an apolipoprotein that is in the SAA family and it is constitutively translated. Previously, acute‐phase SAA1 and SAA2 levels were associated with venous thromboembolism (VTE). We investigated the association of plasma SAA4 with VTE and the role of SAA4 in coagulation. The association of SAA4 with VTE in a case‐control study of adult VTE subjects (N = 113 each group) and the effects of recombinant SAA4 on plasma blood coagulation assays and prothrombin activation initiated by factor Xa were evaluated. Plasma SAA4 levels in VTE subjects were higher vs. controls (48.1 vs. 38.4 µg/mL; P 
ISSN:2475-0379
2475-0379
DOI:10.1002/rth2.12291