Calcitriol versus Cholecalciferol on Biochemical Markers of Metabolic Bone Disease in Very Low Birth Weight Infants: A Randomized Clinical Trial

There are limited data on the use of calcitriol (1, 25-dihydroxycholecalciferol) to prevent or treat MBD in preterm infants. [...]this study aimed to compare the preventive effect of calcitriol and cholecalciferol on the biochemical markers of MBD in preterm infants. According to a hypothesis, calcitriol could also prevent MTB and its biomarkers. According to the protocol of Parenteral Nutrition of preterm infants in the NICU, all infants received elemental calcium with dose of 60-80mg/Kg/ day of as Calcium (Gluconate Calcium 10 %) and elemental phosphor with a dose of 46-60 mg/Kg/day as phosphor (Glycophose by Fresenius Kabi USA) from the very first postnatal days with a molar Ca:P ratio 1.3:1 in mg. [...]all infants received minimal enteral feeding by breast milk from the second day after delivery. [...]we measured the infants' Serum, urine phosphate and serum, urine creatinine.