Influence of the Flexible Liposomes on the Skin Deposition of a Hydrophilic Model Drug, Carboxyfluorescein : Dependency on Their Composition

This study focuses on the effect of different flexible liposomes containing sodium cholate, Tween 80, or cineol on skin deposition of carboxyfluorescein (CF). Size distribution, morphology, zeta potential, and stability of the prepared vesicles were evaluated. The influence of these systems on the s...

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Veröffentlicht in:	TheScientificWorld 2012-01, Vol.2012 (2012), p.1-9
Hauptverfasser:	Badran, Mohamed, al-Omrani, Abdullah, Shalaby, Khaled
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biomedical materials Cineole Composition effects Cryoelectron Microscopy Deposition Drug delivery Drug delivery systems Drugs Entrapment Ethanol Fluoresceins - pharmacokinetics Formulations Lipids Liposomes Membranes Membranes, Artificial Microscopy, Electron, Transmission Particle Size Particle size distribution Pharmaceutical sciences Physiological aspects Polydispersity Rats Size distribution Skin Skin - metabolism Sodium Sodium cholate Stability analysis Vehicles Zeta potential
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Beschreibung
Zusammenfassung:	This study focuses on the effect of different flexible liposomes containing sodium cholate, Tween 80, or cineol on skin deposition of carboxyfluorescein (CF). Size distribution, morphology, zeta potential, and stability of the prepared vesicles were evaluated. The influence of these systems on the skin deposition of CF utilizing rat skin as membrane model was investigated. Results showed that all of the investigated liposomes had almost spherical shapes with low polydispersity (PDI
ISSN:	2356-6140 1537-744X 1537-744X
DOI:	10.1100/2012/134876