P2.10 Metabolic Syndrome does Not have an Independent Impact on Ultrasound Indices of Preclinical Cardiovascular Disease

Background whether metabolic syndrome (MetS) has an independent impact on development of cardiovascular (CV) disease is uncertain. Aim: to evaluate indices of preclinical CV disease in subjects with MetS. Methods: we studied 160 subjects: 50 with MetS (ATP III criteria, age 49 ± 12, BMI 36 ± 7, 12 diabetics) and 110 healthy age-matched controls (NL: 59 males, age 47 ± 9, BMI 28 ± 6). Left ventricular (LV) mass and function were assessed by echocardiography, and common carotid artery (CCA) stiffness (b index, pressure-strain elastic modulus EP, and local wave speed WS) by wall tracking (Aloka SSD-5500). Results: MetS+ showed higher (p < 0.01) EP (138 ± 62 vs 110 ± 40 kPa), β (9.5 ± 3.8 vs 8.2 ± 2.3), WS (7 ± 1.5 vs 6 ± 1.1 cm/s), cardiac index (3.2 ± 0.7 vs 2.8 ± 0.5 l/min/m 2 ), and LV mass index (LVMI) (102 ± 24 vs 88 ± 21 g/m 2 ), and lower peripheral resistance (TPR: 0.016 ± 0.004 vs 0.018 ± 0.004 dyne/s/cm 5 , p < 0.05) than NL. In multivariate analysis (dependent variable WS and independent variables age, sex, SBP, DBP, waist circumference, BMI, triglyceride, HDL-cholesterol and blood glucose levels), the main independent correlated of WS were age and SBP (adjusted r 2 = 0.53, p < 0.01), while male gender and waist were predictors of LVM (adjusted r 2 = 0.56, p < 0.01). Conclusions: in subjects without clinical CV disease and various clustering of risk factors, MetS does not seem to represent an independent predictor of preclinical CV involvement. Large artery stiffness appears mainly related to age and BP, and LVM by body size.