Circadian clock dysregulation: a potential mechanism of depression in obstructive sleep apnea patients

Circadian clock dysregulation: a potential mechanism of depression in obstructive sleep apnea patients

Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders. Our study aims to investigate the association of circadian clock gene expressions, and the presence and severity of depressive symptoms in OSA patients. The study included 184 individuals, who underwent polysom...

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Veröffentlicht in:Translational psychiatry 2024-10, Vol.14 (1), p.423-6, Article 423
Hauptverfasser: Gabryelska, Agata, Turkiewicz, Szymon, Kaczmarski, Piotr, Gajewski, Adrian, Białasiewicz, Piotr, Strzelecki, Dominik, Chałubiński, Maciej, Sochal, Marcin
Format: Artikel
Sprache:eng
Schlagworte:
38
692/420/2489
692/699/476
Adult
ARNTL Transcription Factors
Basic Helix-Loop-Helix Transcription Factors - genetics
Behavioral Sciences
Biological Psychology
Circadian Clocks - genetics
Circadian rhythm
Circadian Rhythm - genetics
CLOCK Proteins - genetics
Cryptochromes
Depression - genetics
Female
Gene expression
Humans
Male
Medicine
Medicine & Public Health
Mental depression
Middle Aged
Nerve Tissue Proteins
Neurosciences
Pharmacotherapy
Polysomnography
Psychiatry
Questionnaires
Severity of Illness Index
Sleep apnea
Sleep Apnea, Obstructive - genetics
Sleep Apnea, Obstructive - physiopathology
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Zusammenfassung:Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders. Our study aims to investigate the association of circadian clock gene expressions, and the presence and severity of depressive symptoms in OSA patients. The study included 184 individuals, who underwent polysomnography (PSG) and had their peripheral blood collected in the evening before and the morning after the PSG. Patients were divided into two groups: the OSA (apnea-hypopnea index (AHI) > 5) and the control group (AHI 
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-024-03134-0