Research Progress of Biomarkers of Sepsis-Associated Encephalopathy

Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE.