Hyperoxia for accidental hypothermia and increased mortality: a post-hoc analysis of a multicenter prospective observational study

Supraphysiologic oxygen administration causes unfavorable clinical outcomes in various diseases, including traumatic brain injury, post-cardiac arrest syndrome, and acute lung injury. Accidental hypothermia is a critical illness that reduces oxygen demands, and excessive oxygen is likely to emerge....

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Veröffentlicht in:	Critical care (London, England) England), 2023-04, Vol.27 (1), p.131-131, Article 131
Hauptverfasser:	Yamamoto, Ryo, Yoshizawa, Jo, Takauji, Shuhei, Hayakawa, Mineji, Sasaki, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Arterial partial pressure of oxygen Body temperature Brain research Care and treatment Chi-square test Clinical outcomes Comorbidity Critical care Critically ill Data collection Forecasts and trends Hemodynamics Hospital Mortality Hospitals Humans Hyperoxemia Hyperoxia Hyperoxia - complications Hypothermia Hypothermia - complications Injuries Intensive care Laboratories Mortality Observational studies Oxygen Oxygen toxicity Patients Prevention Reactive oxygen species Regression analysis Retrospective Studies Risk factors Severe hypothermia Ventilators Vital signs
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Zusammenfassung:	Supraphysiologic oxygen administration causes unfavorable clinical outcomes in various diseases, including traumatic brain injury, post-cardiac arrest syndrome, and acute lung injury. Accidental hypothermia is a critical illness that reduces oxygen demands, and excessive oxygen is likely to emerge. This study aimed to determine whether hyperoxia would be associated with increased mortality in patients with accidental hypothermia. A post-hoc analysis of a nationwide multicenter prospective observational study (ICE-CRASH study) on patients with accidental hypothermia admitted in 2019-2022 was conducted. Adult patients without cardiac arrest whose core body temperature was
ISSN:	1364-8535 1466-609X 1364-8535 1366-609X
DOI:	10.1186/s13054-023-04407-8