Validation of claims-based indicators used to identify flare-ups in inflammatory bowel disease

Validation of claims-based indicators used to identify flare-ups in inflammatory bowel disease

Background & Aims: There are currently no validated claims-based indicators for identifying a worsening of disease in patients with inflammatory bowel disease (IBD). Therefore, we aimed to develop and validate indicators that identify flare-ups of IBD using data from Danish nationwide registries...

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Veröffentlicht in:Therapeutic advances in gastroenterology 2021, Vol.14, p.17562848211004841-17562848211004841
Hauptverfasser: Burisch, Johan, Zhang, He, Choong, Casey Kar-Chan, Nelson, David, Naegeli, April, Gibble, Theresa, Goetz, Iris, Egeberg, Alexander
Format: Artikel
Sprache:eng
Schlagworte:
Gastroenterology
Inflammatory bowel disease
Original Research
Steroids
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Zusammenfassung:Background & Aims: There are currently no validated claims-based indicators for identifying a worsening of disease in patients with inflammatory bowel disease (IBD). Therefore, we aimed to develop and validate indicators that identify flare-ups of IBD using data from Danish nationwide registries. Methods: Using Danish nationwide administrative data, we identified all patients with Crohn’s disease (CD) or ulcerative colitis (UC) who had at least one measurement of faecal calprotectin between 1 January 2015 and 31 June 2017. We tested several different claims-based indicators of disease flare-ups against levels of faecal (F-)calprotectin (no flare-up:
ISSN:1756-2848
1756-283X
1756-2848
DOI:10.1177/17562848211004841