P10.08: Comparative Investigation of Mechanical Characteristics of Stable and Unstable Carotid Atherosclerotic Plaques

The prognosis of patients with carotid atherosclerosis is determined by the factor of unstable atherosclerotic plaque. Change of longitudinal strain in junction place of healthy artery wall to plaque determined by local artery elasticity and leads to instability. Aim of the study Comparative investigation of mechanical characteristics of the stable and unstable plaques in a carotid artery. Methods In the main group (MGr) were studied 16 plaques with stenosis 70–90%, and control group (CGr) 33 plaques with stenosis 25–45%. Carotid ultrasound examinations (PHILIPS iU22) were performed for estimated structure and stenosis of plaques. The “healthy” wall stiffness (free from plaques -βhw) and plaques zone stiffness (in adventitia -βadv and in plaques surface -βpl) were estimated using echo-tracking method by ALOKAα7 in B/M mode ultrasound imaging. Results In the MGr majority of plaques had structure with hypoechogenic area (>50%) and calcification, third plaques had rough or ulcerated surface. In CGr dominated heterogeneous plaques with smooth surface. In both groups βhw was significantly lower, than βadv (MGr: 8,95±3,14 vs 22,73±10,43, CGr: 9,43±2,64 vs 14,45±6,7, p