Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-12, Vol.25 (24), p.5906
Hauptverfasser:	Hassan, Sk Sarif, Ghosh, Shinjini, Attrish, Diksha, Choudhury, Pabitra Pal, Aljabali, Alaa A A, Uhal, Bruce D, Lundstrom, Kenneth, Rezaei, Nima, Uversky, Vladimir N, Seyran, Murat, Pizzol, Damiano, Adadi, Parise, Soares, Antonio, El-Aziz, Tarek Mohamed Abd, Kandimalla, Ramesh, Tambuwala, Murtaza M, Azad, Gajendra Kumar, Sherchan, Samendra P, Baetas-da-Cruz, Wagner, Takayama, Kazuo, Serrano-Aroca, Ángel, Chauhan, Gaurav, Palu, Giorgio, Brufsky, Adam M
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Amino acids Angiotensin Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - genetics Angiotensin-Converting Enzyme 2 - metabolism Animal behavior Animals Bioinformatics Cats Cattle Chimpanzees Coronaviruses COVID-19 COVID-19 - genetics COVID-19 - metabolism COVID-19 - transmission Disease transmission Dogs Humans Mortality Mutation Pan troglodytes Pelodiscus sinensis Peptidyl-dipeptidase A Phylogenetics Protein Domains Proteins Respiratory diseases SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - metabolism Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Species Specificity Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism transmission viral spike receptor-binding domain Zebrafish
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25245906