Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation

Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation

Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expr...

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Veröffentlicht in:Journal of Immunology Research 2018-01, Vol.2018 (2018), p.1-7
Hauptverfasser: D'Ettorre, Gabriella, Scagnolari, Carolina, Brenchley, Jason M., Pinacchio, Claudia, Scheri, Giuseppe Corano, Statzu, Maura, Santinelli, Letizia, Ceccarelli, Giancarlo, Innocenti, Giuseppe Pietro, Vullo, Vincenzo, Antonelli, Guido
Format: Artikel
Sprache:eng
Schlagworte:
Acquired immune deficiency syndrome
AIDS
Antiretroviral agents
Antiretroviral therapy
Bacteria
Biopsy
Cytokines
Dietary supplements
Drug therapy
Endoscopy
Gene expression
Gut-associated lymphoid tissues
HIV
Human immunodeficiency virus
Immunology
Infections
Infectious diseases
Interferon
Leukocytes (mononuclear)
Lymphoid tissue
Mucosa
Pathogenesis
Peripheral blood mononuclear cells
Probiotics
Supplements
Viral infections
γ-Interferon
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Zusammenfassung:Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation.
ISSN:2314-8861
2314-7156
DOI:10.1155/2018/1738676