New insights into pulmonary hemorrhage

In this issue of Pediatric Investigation, Tang et al describe a cohort of pediatric patients with interstitial lung disease associated with heterozygous SFTPC mutations, with the goal of highlighting disease manifestations and clinical outcomes related to surfactant protein C (SP‐C) deficiency. SFTPC‐associated surfactant deficiency is an autosomal dominant monogenic cause of interstitial lung disease, causing a range of pulmonary symptoms. SFTPC mutations that lead to ER stress can cause pulmonary interstitial lung disease and have now been associated with pulmonary hemorrhage.