Emergence of Novel Norovirus GII.4 Variant

We detected a novel GII.4 variant with an amino acid insertion at the start of epitope A in viral protein 1 of noroviruses from the United States, Gabon, South Africa, and the United Kingdom collected during 2017-2022. Early identification of GII.4 variants is crucial for assessing pandemic potentia...

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Veröffentlicht in:	Emerging infectious diseases 2024-01, Vol.30 (1), p.163-167
Hauptverfasser:	Chhabra, Preeti, Tully, Damien C, Mans, Janet, Niendorf, Sandra, Barclay, Leslie, Cannon, Jennifer L, Montmayeur, Anna M, Pan, Chao-Yang, Page, Nicola, Williams, Rachel, Tutill, Helena, Roy, Sunando, Celma, Cristina, Beard, Stuart, Mallory, Michael L, Manouana, Gédéon Prince, Velavan, Thirumalaisamy P, Adegnika, Ayola Akim, Kremsner, Peter G, Lindesmith, Lisa C, Hué, Stéphane, Baric, Ralph S, Breuer, Judith, Vinjé, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	acute gastroenteritis Amino acids Analysis Antibodies Antigenic determinants Caliciviridae Infections - epidemiology Care and treatment Control Diagnosis Dispatch Emergence of Novel Norovirus GII.4 Variant enteric infections Epidemics Gastroenteritis Gastroenteritis - epidemiology Genetic variation Genomes Genomics Genotype Genotype & phenotype Humans Identification and classification Ligands Medical laboratories Medical research Medicine, Experimental Mutation Norovirus Norovirus - genetics Pandemics Phylogeny Proteins Risk factors RNA polymerase Trends United Kingdom United States Viral proteins Viruses
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Zusammenfassung:	We detected a novel GII.4 variant with an amino acid insertion at the start of epitope A in viral protein 1 of noroviruses from the United States, Gabon, South Africa, and the United Kingdom collected during 2017-2022. Early identification of GII.4 variants is crucial for assessing pandemic potential and informing vaccine development.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid3001.231003